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bacteria:t3e:t3e

Type III effectors

Xanthomonas type III effectors

Class Family Synonyms Related proteins RefSeq ID (GenBank ID) Function / Features
AvrBs1 AvrBs1 AvrA WP_011037255.1
AvrBs2 AvrBs2 WP_039418336.1 Glycerophosphodiester phosphodiesterase domain
AvrBs3 AvrBs3 PthA, PthB, PthN, PthXo, AvrXa7, AvrXa27, TALE RipTAL WP_011052943.1 TAL effector repeat; Transcription activator in eukaryotic host cell; Nuclear localization
XopB XopB HopD1 (HopPtoD1, AvrPphD1), RipD WP_039417318.1
XopC XopC1 RipC2 WP_011347616.1 Phosphoribosyltransferase domain; Haloacid dehalogenase-like hydrolase
XopC XopC2 RipC1 WP_041183113.1
XopD XopD WP_228949438.1 C48-family SUMO cysteine protease (Ulp1 protease family); EAR motif; DNA binding; Nuclear localization
XopE XopE1 AvrXacE1 HopX (AvrPphE), RipE1 WP_011345998.1 Putative transglutaminase
XopE XopE2 AvrXacE3, AvrXccE1 HopX (AvrPphE), RipE1 WP_011347479.1 Putative transglutaminase
XopE XopE3 AvrXacE2 HopX (AvrPphE), RipE1 WP_011052114.1 Putative transglutaminase
XopE XopE4 RipE1 WP_244170787.1 Putative transglutaminase
XopE XopE5 HopX (AvrPphE), RipE1 WP_260607984.1 Putative transglutaminase
XopF XopF1 Hpa4 WP_011346095.1
XopF XopF2 WP_011348008.1
XopF XopF3 WP_039005675.1
XopG XopG1 HopH (HopPtoH), RipAX2 WP_011346758.1 Peptidase_M91 superfamily; HEXXH motif, typical of zinc metallopeptidases
XopG XopG2 HopH (HopPtoH), RipAX2 WP_011038360.1 Peptidase_M91 superfamily; HEXXH motif, typical of zinc metallopeptidases
XopG XopG3 HopH (HopPtoH), RipAX1 WP_084217840.1 Peptidase_M91 superfamily; HEXXH motif, typical of zinc metallopeptidases
XopH XopH1 AvrBs1.1, AvrBs7 HopAO1 (HopPtoD2), RipBL WP_011345706.1 Protein tyrosine phosphatase-like phytase; Tyrosine-specific protein phosphatase
XopH XopH2 HopAO1 (HopPtoD2), RipBL WP_010377341.1 Protein tyrosine phosphatase-like phytase; Tyrosine-specific protein phosphatase
XopI XopI1 WP_011346406.1 F-box domain
XopI XopI2 WP_010367684.1 F-box domain
XopJ XopJ1 HopZ1, RipP1 WP_011347382.1 Ser/Thr acetyltransferase
XopJ XopJ2 AvrBsT HopZ1, RipP1 WP_074052319.1 Ser/Thr acetyltransferase
XopJ XopJ3 AvrRxv HopZ1, RipP1 WP_011346137.1 Ser/Thr acetyltransferase
XopJ XopJ4 AvrXv4 HopZ1, RipP1 (formerly PopP1) WP_008572727.1 Ser/Thr acetyltransferase
XopJ XopJ5 AvrXccB HopZ1, RipK, RipP1 WP_228442257.1 Ser/Thr acetyltransferase
XopJ XopJ6 Unpublished, personal communication
XopK XopK WP_027703763.1
XopL XopL RipAC (formerly PopC) WP_218498620.1 LRR motif; LRR domain
XopM XopM WP_011346113.1
XopN XopN HopAU1 WP_011348010.1 ARM/HEAT repeat
XopO XopO HopK1 (HopPtoK, HolPtoAB) N-terminal domain, AvrRps4 WP_011346566.1 AvrRps4 C-terminal region
XopP XopP RipH3 (formerly Hlk) WP_104613784.1
XopQ XopQ HopQ1 (HolPtoQ), RipB WP_011349176.1 Inosine/uridine-preferring nucleoside hydrolase
XopR XopR WP_011260681.1
XopS XopS WP_039418869.1
XopT XopT WP_199285673.1 Plectin-repeat
XopU XopU WP_011408937.1
XopV XopV RipAD WP_011409498.1
XopW XopW WP_228329674.1
XopX XopX HopAE1 (HolPsyAE), RipBI WP_011346212.1
XopY XopY WP_011408080.1
XopZ XopZ1 HopAS1 WP_011259177.1
XopZ XopZ2 HopAS1 WP_039421390.1
XopAA XopAA Ecf HopAE1 (HolPsyAE), weakly related to RipBI WP_041855088.1 Early chlorosis factor; Proteasome/cyclosome repeat
XopAB XopAB weakly related to XopN WP_011409110.1
XopAC XopAC AvrAC RipAC (formerly PopC) WP_011269629.1 LRR motif; LRR domain; Fido domain; Vascular hypersensitivity in Arabidopsis landrace Col-0
XopAD XopAD RipS3 WP_011409710.1 SKWP repeat protein; Armadillo-like helical repeat; Armadillo-type fold; RelA/SpoT superfamily
XopAE XopAE HpaF/HpaG RipAC (formerly PopC) WP_011050288.1 LRR motif; LRR domain
XopAF XopAF1 AvrXv3 HopAF1 (HopPtoJ), RipBD WP_008577605.1
XopAF XopAF2 HopAF1 (HopPtoJ), RipBD WP_227479740.1
XopAG XopAG1 AvrGf1 HopG1 (HopPtoG), HolPtoW, RipO1 WP_272820829.1
XopAG XopAG2 AvrGf2 HopG1 (HopPtoG), HolPtoW, RipO1 WP_007970248.1
XopAH XopAH AvrXccC AvrB/AvrC (AvrPphC) WP_011037263.1 AvrB/AvrC-family avirulence protein
XopAI XopAI HopO1 (HopPtoO, HopPtoS), HopAI1 (HolPtoAI) WP_011052119.1 NAD:arginine ADP-ribosyltransferase
XopAJ XopAJ AvrRxo1 WP_014504815.1 P-loop containing nucleoside triphosphate hydrolase
XopAK XopAK HopK1 (HopPtoK, HolPtoAB) C-terminal domain, RipBQ WP_269466020.1
XopAL XopAL1 Eop3, weakly similar to HopX, RipE2 WP_274360846.1
XopAL XopAL2 Eop3, RS_T3E_Hyp14 WP_012437264.1
XopAM XopAM HopR1, RipR WP_012438997.1 AvrE-family effector
XopAN XopAN
XopAO XopAO AvrRpm1, RipBA WP_162267513.1
XopAP XopAP RipAL WP_236504155.1 α/β hydrolase fold; Class-3 lipase
XopAQ XopAQ RipAH/RipAG WP_233366621.1
XopAR XopAR RipBE (APO95022.1)
XopAS XopAS HopAS1 WP_229015407.1
XopAT XopAT (AEL06363.1)
XopAU XopAU WP_041855031.1 Serine/threonine kinase; Protein kinase domain; ATP-binding site
XopAV XopAV1 WP_065628638.1
XopAV XopAV2 WP_011269951.1
XopAW XopAW WP_011348129.1 Calcium-binding protein; EF-hand domain; Calcium-binding site
XopAX XopAX WP_041854960.1
XopAY XopAY
XopAZ XopAZ WP_104549896.1 SlpA superfamily; FKBP-type peptidyl-prolyl cis-trans isomerase
XopBA XopBA HopW1, RipBP WP_227478587.1
XopBB XopBB HopF2 (AvrPphF) WP_251761698.1
XopBC = XopAV class
XopBD = XopAT class
XopBE = XopC class
XopBF = XopAV class
XopBG XopBG WP_145953988.1

Avirulence or type III-secreted proteins that are not considered effectors in a narrow sense

Name Synonyms Related proteins RefSeq ID (GenBank ID) Function / Features Reference
AvrXccA1 AvrXca WP_011039290.1 Avirulence protein, perhaps not a T3E Parker et al., 1993
AvrXccA2 WP_274318562.1 Avirulence protein, perhaps not a T3E
HpaA WP_011346100.1 Type III secretion control protein, perhaps not a T3E Lorenz et al., 2008
HpaT WP_058196718.1 Putative translocon protein, not a T3E Pesce et al., 2017
HrpB2 WP_008575450.1 Putative inner rod protein, not a T3E Rossier et al., 2000; Scheibner et al., 2016
HrpE HrpE1 WP_011346098.1 Major subunit of the Hrp pilus Weber et al., 2005; Weber & Koebnik, 2005; Weber & Koebnik, 2006; Gottig et al., 2018
HrpF RipF (formerly PopF) WP_011346092.1 Putative translocon protein, not a T3E Huguet & Bonas, 1997; Meyer et al., 2006
HrpW RipW (formerly PopW) WP_005926112.1 Pectate lyase, perhaps not a T3E Charkowski et al., 1998; Li et al., 2010
XopA Hpa1/HpaG WP_011346111.1 Harpin, perhaps not a T3E Zhu et al., 2000; Kim et al., 2004; Sgro et al., 2012; Wang et al., 2018

References

Charkowski AO, Alfano JR, Preston G, Yuan J, He SY, Collmer A (1998). The Pseudomonas syringae pv. tomato HrpW protein has domains similar to harpins and pectate lyases and can elicit the plant hypersensitive response and bind to pectate. J. Bacteriol. 180: 5211-5217. DOI: 10.1128/JB.180.19.5211-5217.1998

Gottig N, Vranych CV, Sgro GG, Piazza A, Ottado J (2018). HrpE, the major component of the Xanthomonas type three protein secretion pilus, elicits plant immunity responses. Sci. Rep. 8: 9842. DOI: 10.1038/s41598-018-27869-1

Huguet E, Bonas U (1997). HrpF of Xanthomonas campestris pv. vesicatoria encodes an 87-kDa protein with homology to NoIX of Rhizobium fredii. Mol. Plant Microbe Interact. 10: 488-498. DOI: 10.1094/MPMI.1997.10.4.488

Kim JG, Jeon E, Oh J, Moon JS, Hwang I (2004). Mutational analysis of Xanthomonas harpin HpaG identifies a key functional region that elicits the hypersensitive response in nonhost plants. J. Bacteriol. 186: 6239-6247. DOI: 10.1128/JB.186.18.6239-6247.2004

Li JG, Liu HX, Cao J, Chen LF, Gu C, Allen C, Guo JH (2010). PopW of Ralstonia solanacearum, a new two-domain harpin targeting the plant cell wall. Mol. Plant Pathol. 11: 371-381. DOI: 10.1111/j.1364-3703.2010.00610.x

Lindeberg M, Stavrinides J, Chang JH, Alfano JR, Collmer A, Dangl JL, Greenberg JT, Mansfield JW, Guttman DS (2005). Proposed guidelines for a unified nomenclature and phylogenetic analysis of type III Hop effector proteins in the plant pathogen Pseudomonas syringae. Mol. Plant Microbe Interact. 18: 275-282. DOI: 10.1094/MPMI-18-0275

Lorenz C, Kirchner O, Egler M, Stuttmann J, Bonas U, Büttner D (2008). HpaA from Xanthomonas is a regulator of type III secretion. Mol. Microbiol. 69: 344-360. DOI: 10.1111/j.1365-2958.2008.06280.x

Meyer D, Cunnac S, Guéneron M, Declercq C, Van Gijsegem F, Lauber E, Boucher C, Arlat M (2006). PopF1 and PopF2, two proteins secreted by the type III protein secretion system of Ralstonia solanacearum, are translocators belonging to the HrpF/NopX family. J. Bacteriol. 188: 4903-4917. DOI: 10.1128/JB.00180-06

Parker JE, Barber CE, Fan MJ, Daniels MJ (1993). Interaction of Xanthomonas campestris with Arabidopsis thaliana: characterization of a gene from X. c. pv. raphani that confers avirulence to most A. thaliana accessions. Mol. Plant Microbe Interact. 6: 216-224. DOI: 10.1094/mpmi-6-216

Peeters N, Carrère S, Anisimova M, Plener L, Cazalé AC, Genin S (2013). Repertoire, unified nomenclature and evolution of the Type III effector gene set in the Ralstonia solanacearum species complex. BMC Genomics 14: 859. DOI: 10.1186/1471-2164-14-859

Pesce C, Jacobs JM, Berthelot E, Perret M, Vancheva T, Bragard C, Koebnik R (2017). Comparative genomics identifies a novel conserved protein, HpaT, in proteobacterial type III secretion systems that do not possess the putative translocon protein HrpF. Front. Microbiol. 8: 1177. DOI: 10.3389/fmicb.2017.01177

Rossier O, Van den Ackerveken G, Bonas U (2000). HrpB2 and HrpF from Xanthomonas are type III-secreted proteins and essential for pathogenicity and recognition by the host plant. Mol. Microbiol. 38: 828-838. DOI: 10.1046/j.1365-2958.2000.02173.x

Sabbagh CRR, Carrere S, Lonjon F, Vailleau F, Macho AP, Genin S, Peeters N (2019). Pangenomic type III effector database of the plant pathogenic Ralstonia spp. PeerJ 7: e7346. DOI: 10.7717/peerj.7346

Scheibner F, Schulz S, Hausner J, Marillonnet S, Büttner D (2016). Type III-dependent translocation of HrpB2 by a nonpathogenic hpaABC mutant of the plant-pathogenic bacterium Xanthomonas campestris pv. vesicatoria. Appl. Environ. Microbiol. 82: 3331-3347. DOI: 10.1128/AEM.00537-16

Sgro GG, Ficarra FA, Dunger G, Scarpeci TE, Valle EM, Cortadi A, Orellano EG, Gottig N, Ottado J (2012). Contribution of a harpin protein from Xanthomonas axonopodis pv. citri to pathogen virulence. Mol. Plant Pathol. 13: 1047-1059. DOI: 10.1111/j.1364-3703.2012.00814.x

Wang X, Zhang L, Ji H, Mo X, Li P, Wang J, Dong H (2018). Hpa1 is a type III translocator in Xanthomonas oryzae pv. oryzae. BMC Microbiol. 18: 105. DOI: 10.1186/s12866-018-1251-3

Weber E, Koebnik R (2005). Domain structure of HrpE, the Hrp pilus subunit of Xanthomonas campestris pv. vesicatoria. J. Bacteriol. 187: 6175-6186. DOI: 10.1128/JB.187.17.6175-6186.2005

Weber E, Koebnik R (2006). Positive selection of the Hrp pilin HrpE of the plant pathogen Xanthomonas. J. Bacteriol. 188: 1405-1410. DOI: 10.1128/JB.188.4.1405-1410.2006

Weber E, Ojanen-Reuhs T, Huguet E, Hause G, Romantschuk M, Korhonen TK, Bonas U, Koebnik R (2005). The type III-dependent Hrp pilus is required for productive interaction of Xanthomonas campestris pv. vesicatoria with pepper host plants. J. Bacteriol. 187: 2458-2468. DOI: 10.1128/JB.187.7.2458-2468.2005

Zhu W, MaGbanua MM, White FF (2000). Identification of two novel hrp-associated genes in the hrp gene cluster of Xanthomonas oryzae pv. oryzae. J. Bacteriol. 182: 1844-1853. DOI: 10.1128/JB.182.7.1844-1853.2000

bacteria/t3e/t3e.txt · Last modified: 2024/03/16 11:32 by rkoebnik