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Molecular Diagnosis and Diversity for Regulated Xanthomonas
Bacterial virulence factors
This DokuWiki is based upon work from COST Action CA16107 EuroXanth, supported by COST (European Cooperation in Science and Technology)
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Author: Ralf Koebnik
Internal reviewer:
Expert reviewer: WANTED!
Class: XopBA
Family: XopBA
Prototype: XopBA (Xanthomonas euvesicatoria pv. euvesicatoria; strain 66b)
RefSeq ID: WP_227478587.1 (500 aa)
3D structure: Unknown
XopBA was discovered by homology to HopW/HopPmaA in Pseudomonas syringae (70% aa sequence identity) and EspW in Escherichia coli (30% aa sequence identity) (Stavrinides & Guttman, 2004; Sandu et al., 2017).
No evidence.
Unknown.
Ectopic expression of the distant homolog in E. coli, EspW, results in formation of unique membrane protrusions (Sandu et al., 2017)
The distant homolog in E. coli, EspW, and Kif15 colocalized in cotransfected cells, while ectopically expressed Kif15 localized to the actin pedestals following EHEC infection (Sandu et al., 2017).
The distant homolog in E. coli, EspW, modulates actin dynamics in a Rac1-dependent manner (Sandu et al., 2017).
The distant homolog in E. coli, EspW, was found to interact with the motor protein Kif15 in a yeast two-hybrid screen (Sandu et al., 2017).
Yes (e.g., X. euvesicatoria, X. citri, X. transclucens, X. vasicola).
Yes (Acidovorax spp., Erwinia spp., Pseudomonas syringae).
Sandu P, Crepin VF, Drechsler H, McAinsh AD, Frankel G, Berger CN (2017). The enterohemorrhagic Escherichia coli effector EspW triggers actin remodeling in a Rac1-dependent manner. Infect. Immun. 85: e00244-17. doi: 10.1128/IAI.00244-17
Stavrinides J, Guttman DS (2004). Nucleotide sequence and evolution of the five-plasmid complement of the phytopathogen Pseudomonas syringae pv. maculicola ES4326. J. Bacteriol. 186: 5101-5115. doi: 10.1128/JB.186.15.5101-5115.2004
