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--- bacteria:t3e:xopi [2025/02/21 13:03] – [Biological function] rkoebnik
+++ bacteria:t3e:xopi [2025/02/24 16:35] (current) – [The Type III Effector XopI from //Xanthomonas//] rkoebnik
@@ Line 1: / Line 1: @@
 ====== The Type III Effector XopI from //Xanthomonas// ======
-Author: [[https://www.researchgate.net/profile/Joana_Costa12|Joana Costa]] & Trainees from the 2<sup>nd</sup> EuroXanth Training School (Maria Laura Destefanis, [[https://www.researchgate.net/profile/Katarina_Gasic|Katarina Gašić]], [[https://www.researchgate.net/profile/G_Licciardello|Grazia Licciardello]], Tamara Popović)\\
+Author: [[https://www.researchgate.net/profile/Joana_Costa12|Joana Costa]] & Trainees from the 2<sup>nd</sup>  EuroXanth Training School (Maria Laura Destefanis, [[https://www.researchgate.net/profile/Katarina_Gasic|Katarina Gašić]], [[https://www.researchgate.net/profile/G_Licciardello|Grazia Licciardello]], Tamara Popović)\\
-Internal reviewer: Isabel Rodrigues
+Internal reviewer: [[https://www.researchgate.net/profile/Isabel-Rodrigues-12|Isabel Rodrigues]]
 Class: XopI\\
@@ Line 29: / Line 29: @@
 === Localization ===
-XopI is translocated by the 85*Δ//hpaB// strain, that belong to the class B.
+XopI is translocated by the 85*Δ//hpaB// strain, thus belonging to the class B (Büttner //et al.//, 2006).
 === Enzymatic function ===
-These phenotypes can be ascribed either to the virulence activity of the effectors in plant cells, or to their recognition by the plant surveillance system. As shown in [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883825/figure/f0001/|**Fig. 1A**]] and [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883825/table/t0001/|**Table 1**]], the XopE1, XopF2, XopH, **XopI**, XopM, XopQ, XopV, AvrBs1 and AvrXv4 effectors partially or fully inhibited cell death triggered by at least one of the cell death inducers.
+The T3Es XopE1, XopF2, XopH, **XopI**, XopM, XopQ, XopV, AvrBs1 and AvrXv4 partially or fully inhibited cell death triggered by at least one of the cell death inducers (Teper //et al.//, 2015).
 === Interaction partners ===
-XopR and XopS belong to //Xcv// translocation class A, comprising T3Es whose translocation into plant cells is completely dependent on HpaB, whereas XopB, XopG, **XopI**, XopK, XopM and XopV were assigned to class B, because they are still translocated in the absence of HpaB (Büttner //et al.//, 2006). Both new class A effectors lack homology to known proteins or motifs, so that their molecular function remains elusive. By contrast, the class B effectors comprise the putative enzyme XopG, a member of the HopH family of putative zinc metalloproteases. Other effectors possess interesting features, for example XopI contains an F‐box motif typical for eukaryotic proteins playing a role in the ubiquitin‐26S proteasome system (UPS). The UPS controls protein stability in eukaryotes and appears to be a favorable target for many T3Es, for example members of the GALA family, which strongly contribute to the virulence of //R. solanacearum// and the E3 ubiquitin ligase AvrPtoB from //P. syringae.//
+XopR and XopS belong to //Xcv// translocation class A, comprising T3Es whose translocation into plant cells depends on HpaB, whereas XopB, XopG, **XopI**, XopK, XopM and XopV were assigned to class B, because they are still translocated in the absence of HpaB (Büttner //et al.//, 2006). Both new class A effectors lack homology to known proteins or motifs, so that their molecular function remains elusive. By contrast, the class B effectors comprise the putative enzyme XopG, a member of the HopH family of putative zinc metalloproteases. Other effectors possess interesting features, for example XopI contains an F‐box motif typical for eukaryotic proteins playing a role in the ubiquitin‐26S proteasome system (UPS). The UPS controls protein stability in eukaryotes and appears to be a favorable target for many T3Es, for example members of the GALA family, which strongly contribute to the virulence of //R. solanacearum// and the E3 ubiquitin ligase AvrPtoB from //P. syringae.//
 ===== Conservation =====

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