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bacteria:t3e:xopba

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bacteria:t3e:xopba [2025/11/15 14:07] – jfpothierbacteria:t3e:xopba [2025/11/24 14:31] (current) – jfpothier
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 The homolog in //Xanthomonas graminis// pv. //arrhenatheri// strain LMG 727 with 77% sequence identity (KM317_RS05475), XopBA<sub>//Xga//LMG727</sub>, was discovered as an ORF that is encoded downstream of a PIP box and a properly spaced ‐10 promoter motif (TTCGB‐N<sub>15</sub> ‐TTCGB‐N<sub>30–32</sub> ‐YANNNT) (Passelergue, 2025) The homolog in //Xanthomonas graminis// pv. //arrhenatheri// strain LMG 727 with 77% sequence identity (KM317_RS05475), XopBA<sub>//Xga//LMG727</sub>, was discovered as an ORF that is encoded downstream of a PIP box and a properly spaced ‐10 promoter motif (TTCGB‐N<sub>15</sub> ‐TTCGB‐N<sub>30–32</sub> ‐YANNNT) (Passelergue, 2025)
-=== (Experimental) evidence for being a T3E === 
  
 +=== (Experimental) evidence for being a T3E ===
 XopBA<sub>//Xga//LMG727</sub> was shown to have a functional type III secretion signal using a reporter fusion with AvrBs1 (Zhao //et al.//, 2013; Passelergue, 2025). XopBA<sub>//Xga//LMG727</sub> was shown to have a functional type III secretion signal using a reporter fusion with AvrBs1 (Zhao //et al.//, 2013; Passelergue, 2025).
 +
 === Regulation === === Regulation ===
 +The presence of a PIP box and a properly spaced ‐10 promoter motif (TTCGB‐N<sub>15</sub> ‐TTCGB‐N<sub>30–32</sub>‐YANNNT) suggests that the //xopBA<sub>Xga LMG727</sub>// gene is under control of HrpG and HrpX (Wengelnik & Bonas, 1996; Wengelnik //et al.//, 1996; Koebnik //et al.//, 2006).
  
-The presence of a PIP box and a properly spaced ‐10 promoter motif (TTCGB‐N<sub>15</sub> ‐TTCGB‐N<sub>30–32</sub> ‐YANNNT) suggests that the //xopBA<sub>Xga</sub>// <sub>LMG727</sub>// gene is under control of HrpG and HrpX (Wengelnik & Bonas, 1996; Wengelnik //et al.//, 1996; Koebnik //et al.//, 2006). 
 === Phenotypes === === Phenotypes ===
- 
 Ectopic expression of the distant homolog in //E. coli//, EspW, results in formation of unique membrane protrusions (Sandu //et al.//, 2017) Ectopic expression of the distant homolog in //E. coli//, EspW, results in formation of unique membrane protrusions (Sandu //et al.//, 2017)
-=== Localization === 
  
 +=== Localization ===
 The distant homolog in //E. coli//, EspW, and Kif15 colocalized in cotransfected cells, while ectopically expressed Kif15 localized to the actin pedestals following EHEC infection (Sandu //et al.//, 2017). The distant homolog in //E. coli//, EspW, and Kif15 colocalized in cotransfected cells, while ectopically expressed Kif15 localized to the actin pedestals following EHEC infection (Sandu //et al.//, 2017).
-=== Enzymatic function === 
  
 +=== Enzymatic function ===
 The distant homolog in //E. coli//, EspW, modulates actin dynamics in a Rac1-dependent manner (Sandu //et al.//, 2017). The distant homolog in //E. coli//, EspW, modulates actin dynamics in a Rac1-dependent manner (Sandu //et al.//, 2017).
-=== Interaction partners === 
  
 +=== Interaction partners ===
 The distant homolog in //E. coli//, EspW, was found to interact with the motor protein Kif15 in a yeast two-hybrid screen (Sandu //et al.//, 2017). The distant homolog in //E. coli//, EspW, was found to interact with the motor protein Kif15 in a yeast two-hybrid screen (Sandu //et al.//, 2017).
  
bacteria/t3e/xopba.1763215648.txt.gz · Last modified: 2025/11/15 14:07 by jfpothier

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