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--- bacteria:t3e:xopba [2025/07/31 12:57] – [Biological function] apasselergue
+++ bacteria:t3e:xopba [2025/08/01 14:04] (current) – [Conservation] rkoebnik
@@ Line 1: / Line 1: @@
 ====== The Type III Effector XopBA from //Xanthomonas// ======
-Author: [[https://www.researchgate.net/profile/Ralf-Koebnik|Ralf Koebnik]], Anna Passelergue
+Author: [[https://www.researchgate.net/profile/Ralf-Koebnik|Ralf Koebnik]], Anna Passelergue\\
 Internal reviewer: [[https://www.researchgate.net/profile/Ralf-Koebnik|Ralf Koebnik]]
 Class: XopBA\\
 Family: XopBA\\
-Prototype: XopBA (XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font>  ) (//Xanthomonas euvesicatoria// pv. //euvesicatoria//; strain 66b), KM317_RS05475 (XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>2</sup></font>  ) (Xanthomonas graminis pv. arrhenatheri; strain LMG 727)\\
+Prototype: XopBA (XopBA<sub>//Xee//66b</sub>) (//Xanthomonas euvesicatoria// pv. //euvesicatoria//; strain 66b), KM317_RS05475 (XopBA<sub>//Xga//LMG727</sub>) (//Xanthomonas graminis// pv. //arrhenatheri//; strain LMG 727)\\
-RefSeq ID: (XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font>  ) [[https://www.ncbi.nlm.nih.gov/protein/WP_227478587.1|WP_227478587.1]] (500 aa),(XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>2</sup></font>  ) [[https://www.ncbi.nlm.nih.gov/protein/WP_231108156.1|WP_231108156.1]] (499 aa)\\
+RefSeq ID: XopBA<sub>//Xee//66b</sub> [[https://www.ncbi.nlm.nih.gov/protein/WP_227478587.1|WP_227478587.1]] (500 aa), XopBA<sub>//Xga//LMG727</sub> [[https://www.ncbi.nlm.nih.gov/protein/WP_231108156.1|WP_231108156.1]] (499 aa)\\
 D structure: Unknown
@@ Line 15: / Line 14: @@
 === How discovered? ===
-XopBA
+XopBA<sub>//Xee//66b</sub> was discovered by homology to HopW/HopPmaA in //Pseudomonas syringae// (70% aa sequence identity) and EspW in //Escherichia coli// (30% aa sequence identity) (Stavrinides & Guttman, 2004; Sandu et al., 2017).
- <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font>  was discovered by homology to HopW/HopPmaA in //Pseudomonas syringae// (70% aa sequence identity) and EspW in //Escherichia coli// (30% aa sequence identity) (Stavrinides & Guttman, 2004; Sandu et al., 2017).
-XopBA
+XopBA<sub>//Xga//LMG727</sub> was discovered as an ORF that is encoded downstream of a PIP box and a properly spaced ‐10 promoter motif (TTCGB‐N<sub>15</sub> ‐TTCGB‐N<sub>30–32</sub> ‐YANNNT) (Passelergue, 2025)
- <font inherit/inherit;;#95a5a6;;inherit><sup>2</sup></font>  was discovered as an ORF that is encoded downstream of a PIP box and a properly spaced ‐10 promoter motif (TTCGB‐N<sub>15</sub> ‐TTCGB‐N<sub>30–32</sub> ‐YANNNT) (Passelergue, 2025)
 === (Experimental) evidence for being a T3E ===
-XopBA
+XopBA<sub>//Xee//66b</sub>: No evidence.
- <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font>  : No evidence.
-XopBA
+XopBA<sub>//Xga//LMG727</sub> was shown to have a functional type III secretion signal using a reporter fusion with AvrBs1 (Zhao //et al.//, 2013).
- <font inherit/inherit;;#95a5a6;;inherit><sup>2 </sup></font>  was shown to have a functional type III secretion signal using a reporter fusion with AvrBs1 (Zhao //et al.//, 2013).
 === Regulation ===
-XopBA
+XopBA<sub>//Xee//66b</sub>: Unknown.
- <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font>  : Unknown.
-The presence of a PIP box and a properly spaced ‐10 promoter motif (TTCGB‐N<sub>15</sub> ‐TTCGB‐N<sub>30–32</sub> ‐YANNNT) suggests that the //xopBA<sup>
+XopBA<sub>//Xga//LMG727</sub>: The presence of a PIP box and a properly spaced ‐10 promoter motif (TTCGB‐N<sub>15</sub> ‐TTCGB‐N<sub>30–32</sub> ‐YANNNT) suggests that the //xopBA<sub>Xga</sub> // <sub>LMG727</sub> //<sup> </sup>  // gene is under control of HrpG and HrpX (Wengelnik & Bonas, 1996; Wengelnik //et al.//, 1996; Koebnik //et al.//, 2006).
- <font inherit/inherit;;#95a5a6;;inherit>2</font>  </sup>   //  gene is under control of HrpG and HrpX (Wengelnik & Bonas, 1996; Wengelnik //et al.//, 1996; Koebnik //et al.//, 2006).
 === Phenotypes ===
-XopBA  <sup>1</sup>  : Ectopic expression of the distant homolog in //E. coli//, EspW, results in formation of unique membrane protrusions (Sandu //et al.//, 2017)
+Ectopic expression of the distant homolog in //E. coli//, EspW, results in formation of unique membrane protrusions (Sandu //et al.//, 2017)
 === Localization ===
-XopBA  <sup>1</sup>  : The distant homolog in //E. coli//, EspW, and Kif15 colocalized in cotransfected cells, while ectopically expressed Kif15 localized to the actin pedestals following EHEC infection (Sandu //et al.//, 2017).
+The distant homolog in //E. coli//, EspW, and Kif15 colocalized in cotransfected cells, while ectopically expressed Kif15 localized to the actin pedestals following EHEC infection (Sandu //et al.//, 2017).
 === Enzymatic function ===
-XopBA  <sup>1</sup>  : The distant homolog in //E. coli//, EspW, modulates actin dynamics in a Rac1-dependent manner (Sandu //et al.//, 2017).
+The distant homolog in //E. coli//, EspW, modulates actin dynamics in a Rac1-dependent manner (Sandu //et al.//, 2017).
 === Interaction partners ===
-XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font> : The distant homolog in //E. coli//, EspW, was found to interact with the motor protein Kif15 in a yeast two-hybrid screen (Sandu //et al.//, 2017).
+The distant homolog in //E. coli//, EspW, was found to interact with the motor protein Kif15 in a yeast two-hybrid screen (Sandu //et al.//, 2017).
 ===== Conservation =====
@@ Line 51: / Line 44: @@
 === In xanthomonads ===
-XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font>  : Yes (//e.g.//, //X. euvesicatoria, X. citri, X. transclucens, X. vasicola//).
+XopBA<sub>//Xee//66b</sub>: Yes (//e.g.//, //X. euvesicatoria, X. citri, X. transclucens, X. vasicola//).
-XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>2</sup></font>  : Yes (//e.g.//, //X. translucens//, //X. hortorum//, //X. vasicola//, //X. populi//,// X. euvesicatoria//, //X. arboricola//, //X//. //axonopodis//, //X. campestris//, //X. bromi//,// X//. //nasturtii//,// X//.// phaseoli//,// X//.// cissicola//, //X. perforans//,// X//. //hyacinthi//).
+XopBA<sub>//Xga//LMG727</sub>: Yes (//e.g.//, //X. translucens//, //X. hortorum//, //X. vasicola//, //X. populi//,// X. euvesicatoria//, //X. arboricola//, //X//. //axonopodis//, //X. campestris//, //X. bromi//,// X//. //nasturtii//,// X//.// phaseoli//,// X//.// cissicola//, //X. perforans//,// X//. //hyacinthi//).
 === In other plant pathogens/symbionts ===
-XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font>  : Yes (//Acidovorax// spp., //Erwinia// spp., //Pseudomonas syringae//).
+XopBA<sub>//Xee//66b</sub>: Yes (//Acidovorax// spp., //Erwinia// spp., //Pseudomonas syringae//).
+XopBA<sub>//Xga//LMG727</sub>: Yes (//e.g.//, //Pseudomonas //spp.,// Erwinia //spp., //Robbsia andropogonis//)
-XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>2</sup></font>  : Yes (//e.g.//, //Pseudomonas //spp.,// Erwinia //spp., //Robbsia andropogonis//)
 ===== References =====

EuroXanth DokuWiki

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