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bacteria:t3e:xopba [2025/07/31 12:54] – apasselerguebacteria:t3e:xopba [2025/08/01 14:04] (current) – [Conservation] rkoebnik
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 ====== The Type III Effector XopBA from //Xanthomonas// ====== ====== The Type III Effector XopBA from //Xanthomonas// ======
  
-Author: [[https://www.researchgate.net/profile/Ralf-Koebnik|Ralf Koebnik]], Anna Passelergue +Author: [[https://www.researchgate.net/profile/Ralf-Koebnik|Ralf Koebnik]], Anna Passelergue\\
 Internal reviewer: [[https://www.researchgate.net/profile/Ralf-Koebnik|Ralf Koebnik]] Internal reviewer: [[https://www.researchgate.net/profile/Ralf-Koebnik|Ralf Koebnik]]
  
 Class: XopBA\\ Class: XopBA\\
 Family: XopBA\\ Family: XopBA\\
-Prototype: XopBA (XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font> ) <font inherit/inherit;;#7f8c8d;;inherit></font> (//Xanthomonas euvesicatoria// pv. //euvesicatoria//; strain 66b), KM317_RS05475 (XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>2</sup></font> ) <font inherit/inherit;;#7f8c8d;;inherit></font> (Xanthomonas graminis pv. arrhenatheri; strain LMG 727)\\ +Prototype: XopBA (XopBA<sub>//Xee//66b</sub>) (//Xanthomonas euvesicatoria// pv. //euvesicatoria//; strain 66b), KM317_RS05475 (XopBA<sub>//Xga//LMG727</sub>) (//Xanthomonas graminis// pv. //arrhenatheri//; strain LMG 727)\\ 
-RefSeq ID: (XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font> ) [[https://www.ncbi.nlm.nih.gov/protein/WP_227478587.1|WP_227478587.1]] (500 aa),(XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>2</sup></font> ) [[https://www.ncbi.nlm.nih.gov/protein/WP_231108156.1|WP_231108156.1]] (499 aa)\\+RefSeq ID: XopBA<sub>//Xee//66b</sub> [[https://www.ncbi.nlm.nih.gov/protein/WP_227478587.1|WP_227478587.1]] (500 aa), XopBA<sub>//Xga//LMG727</sub> [[https://www.ncbi.nlm.nih.gov/protein/WP_231108156.1|WP_231108156.1]] (499 aa)\\
 3D structure: Unknown 3D structure: Unknown
  
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 === How discovered? === === How discovered? ===
  
-XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font>  was discovered by homology to HopW/HopPmaA in //Pseudomonas syringae// (70% aa sequence identity) and EspW in //Escherichia coli// (30% aa sequence identity) (Stavrinides & Guttman, 2004; Sandu et al., 2017).+XopBA<sub>//Xee//66b</sub> was discovered by homology to HopW/HopPmaA in //Pseudomonas syringae// (70% aa sequence identity) and EspW in //Escherichia coli// (30% aa sequence identity) (Stavrinides & Guttman, 2004; Sandu et al., 2017).
  
-XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>2</sup></font>  was discovered as an ORF that is encoded downstream of a PIP box and a properly spaced ‐10 promoter motif (TTCGB‐N<sub>15</sub> ‐TTCGB‐N<sub>30–32</sub> ‐YANNNT) (Passelergue, 2025)+XopBA<sub>//Xga//LMG727</sub> was discovered as an ORF that is encoded downstream of a PIP box and a properly spaced ‐10 promoter motif (TTCGB‐N<sub>15</sub> ‐TTCGB‐N<sub>30–32</sub> ‐YANNNT) (Passelergue, 2025)
 === (Experimental) evidence for being a T3E === === (Experimental) evidence for being a T3E ===
  
-XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font> : No evidence.+XopBA<sub>//Xee//66b</sub>: No evidence.
  
-XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>2 </sup></font> was shown to have a functional type III secretion signal using a reporter fusion with AvrBs1 (Zhao //et al.//, 2013).+XopBA<sub>//Xga//LMG727</sub> was shown to have a functional type III secretion signal using a reporter fusion with AvrBs1 (Zhao //et al.//, 2013).
 === Regulation === === Regulation ===
  
-XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font> : Unknown.+XopBA<sub>//Xee//66b</sub>: Unknown.
  
-The presence of a PIP box and a properly spaced ‐10 promoter motif (TTCGB‐N<sub>15</sub> ‐TTCGB‐N<sub>30–32</sub> ‐YANNNT) suggests that the //xopBA<sup> <font inherit/inherit;;#95a5a6;;inherit>2</font> </sup>  // gene is under control of HrpG and HrpX (Wengelnik & Bonas, 1996; Wengelnik //et al.//, 1996; Koebnik //et al.//, 2006).+XopBA<sub>//Xga//LMG727</sub>: The presence of a PIP box and a properly spaced ‐10 promoter motif (TTCGB‐N<sub>15</sub> ‐TTCGB‐N<sub>30–32</sub> ‐YANNNT) suggests that the //xopBA<sub>Xga</sub> // <sub>LMG727</sub> //<sup> </sup>  // gene is under control of HrpG and HrpX (Wengelnik & Bonas, 1996; Wengelnik //et al.//, 1996; Koebnik //et al.//, 2006).
 === Phenotypes === === Phenotypes ===
  
-XopBA <sup>1</sup> :   Ectopic expression of the distant homolog in //E. coli//, EspW, results in formation of unique membrane protrusions (Sandu //et al.//, 2017)+Ectopic expression of the distant homolog in //E. coli//, EspW, results in formation of unique membrane protrusions (Sandu //et al.//, 2017)
 === Localization === === Localization ===
  
-XopBA <sup>1</sup> :   The distant homolog in //E. coli//, EspW, and Kif15 colocalized in cotransfected cells, while ectopically expressed Kif15 localized to the actin pedestals following EHEC infection (Sandu //et al.//, 2017).+The distant homolog in //E. coli//, EspW, and Kif15 colocalized in cotransfected cells, while ectopically expressed Kif15 localized to the actin pedestals following EHEC infection (Sandu //et al.//, 2017).
 === Enzymatic function === === Enzymatic function ===
  
-XopBA <sup>1</sup> : The distant homolog in //E. coli//, EspW, modulates actin dynamics in a Rac1-dependent manner (Sandu //et al.//, 2017).+The distant homolog in //E. coli//, EspW, modulates actin dynamics in a Rac1-dependent manner (Sandu //et al.//, 2017).
 === Interaction partners === === Interaction partners ===
  
-XopBA <sup>1</sup> : The distant homolog in //E. coli//, EspW, was found to interact with the motor protein Kif15 in a yeast two-hybrid screen (Sandu //et al.//, 2017).+The distant homolog in //E. coli//, EspW, was found to interact with the motor protein Kif15 in a yeast two-hybrid screen (Sandu //et al.//, 2017). 
 ===== Conservation ===== ===== Conservation =====
  
 === In xanthomonads === === In xanthomonads ===
  
-XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font> : Yes (//e.g.//, //X. euvesicatoria, X. citri, X. transclucens, X. vasicola//).+XopBA<sub>//Xee//66b</sub>: Yes (//e.g.//, //X. euvesicatoria, X. citri, X. transclucens, X. vasicola//).
  
-XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>2</sup></font> : Yes (//e.g.//, //X. translucens//, //X. hortorum//, //X. vasicola//, //X. populi//,// X. euvesicatoria//, //X. arboricola//, //X//. //axonopodis//, //X. campestris//, //X. bromi//,// X//. //nasturtii//,// X//.// phaseoli//,// X//.// cissicola//, //X. perforans//,// X//. //hyacinthi//).+XopBA<sub>//Xga//LMG727</sub>: Yes (//e.g.//, //X. translucens//, //X. hortorum//, //X. vasicola//, //X. populi//,// X. euvesicatoria//, //X. arboricola//, //X//. //axonopodis//, //X. campestris//, //X. bromi//,// X//. //nasturtii//,// X//.// phaseoli//,// X//.// cissicola//, //X. perforans//,// X//. //hyacinthi//).
 === In other plant pathogens/symbionts === === In other plant pathogens/symbionts ===
  
-XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>1</sup></font> : Yes (//Acidovorax// spp., //Erwinia// spp., //Pseudomonas syringae//).+XopBA<sub>//Xee//66b</sub>: Yes (//Acidovorax// spp., //Erwinia// spp., //Pseudomonas syringae//). 
 + 
 +XopBA<sub>//Xga//LMG727</sub>: Yes (//e.g.//, //Pseudomonas //spp.,// Erwinia //spp., //Robbsia andropogonis//)
  
-XopBA <font inherit/inherit;;#95a5a6;;inherit><sup>2</sup></font> : Yes (//e.g.//, //Pseudomonas //spp.,// Erwinia //spp., //Robbsia andropogonis//) 
 ===== References ===== ===== References =====
  
bacteria/t3e/xopba.1753962891.txt.gz · Last modified: 2025/07/31 12:54 by apasselergue

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