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bacteria:t3e:xopba [2023/02/16 13:04] – [Biological function] rkoebnik | bacteria:t3e:xopba [2024/12/16 14:51] (current) – [The Type III Effector XopBA from //Xanthomonas//] rkoebnik | ||
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- | ====== | + | ====== |
- | Author: [[https:// | + | Author: [[https:// |
- | Internal reviewer: | + | |
- | Expert reviewer: | + | |
Class: XopBA\\ | Class: XopBA\\ | ||
Family: XopBA\\ | Family: XopBA\\ | ||
- | Prototype: XopBA (// | + | Prototype: XopBA (// |
- | RefSeq ID: [[https:// | + | RefSeq ID: [[https:// |
3D structure: Unknown | 3D structure: Unknown | ||
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=== How discovered? === | === How discovered? === | ||
- | XopAU was discovered by homology to HopW/ | + | XopBA was discovered by homology to HopW/ |
=== (Experimental) evidence for being a T3E === | === (Experimental) evidence for being a T3E === | ||
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=== Phenotypes === | === Phenotypes === | ||
- | Ectopic expression of the distant homolog in //E. coli//, EspW, results in formation of unique membrane protrusions (Sandu et al., 2017) | + | Ectopic expression of the distant homolog in //E. coli//, EspW, results in formation of unique membrane protrusions (Sandu |
=== Localization === | === Localization === | ||
- | The distant homolog in //E. coli//, EspW, and Kif15 colocalized in cotransfected cells, while ectopically expressed Kif15 localized to the actin pedestals following EHEC infection (Sandu et al., 2017). | + | The distant homolog in //E. coli//, EspW, and Kif15 colocalized in cotransfected cells, while ectopically expressed Kif15 localized to the actin pedestals following EHEC infection (Sandu |
=== Enzymatic function === | === Enzymatic function === | ||
- | The distant homolog in //E. coli//, EspW, modulates actin dynamics in a Rac1-dependent manner (Sandu et al., 2017). | + | The distant homolog in //E. coli//, EspW, modulates actin dynamics in a Rac1-dependent manner (Sandu |
=== Interaction partners === | === Interaction partners === | ||
- | The distant homolog in //E. coli//, EspW, was found to interact with the motor protein Kif15 in a yeast two-hybrid screen (Sandu et al., 2017). | + | The distant homolog in //E. coli//, EspW, was found to interact with the motor protein Kif15 in a yeast two-hybrid screen (Sandu |
===== Conservation ===== | ===== Conservation ===== |