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Molecular Diagnosis and Diversity for Regulated Xanthomonas
Bacterial virulence factors
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Author: Steven J. Roberts
Internal reviewer: 
Expert reviewer:
Class: XopAH
Family: XopAH
Prototype: XopAH (AvrXccC) (Xanthomonas campestris pv. campestris strain 8004 - Qian et al., 2005)
RefSeq ID: ABQ10636.1 (440 aa) (gene EF529437.1 1323 bp)
3D structure: Unknown
Search of annotated genome (Castenada et al., 2005).
Secreted XopAH (AvrXccC) proteins were detected in culture fluid from Xcc 8004 and hrcV mutant complemented strains but not from the hrcV mutant (Wang et al., 2007). Insertion and deletion mutants affecting the locus (Xcc2109) in the type strain (Xcc 528) resulted in loss of virulence on the host Florida Broad Leaf Mustard (Castenada et al., 2005).
Promoter activity assays showed that the expression of XopAH (avrXccC) is hrpG/hrpX-dependent (Wang et al., 2007).
This effector is required for full virulence in the susceptible host cabbage (Brassica oleracea) (Wang et al., 2007) and results in avirulence in the resistant host mustard (Brassica napiformis) (Castenada et al., 2005; Wang et al., 2007).
XopAH (AvrXccC) is anchored to the plant plasma membrane, and the N‐terminal myristoylation site (amino acids 2–7: GLcaSK) is essential for its localization (Wang et al., 2007).
Unknown
???
? Only in Xanthomonas campestris pv. campestris?
Yes (AvrB Pseudomonas savastanoi, Pseudomonas syringae)
Castenada A, Reddy JD, El-Yacoubi B, Gabriel DW (2005). Mutagenesis of all eight avr genes in Xanthomonas campestris pv. campestris had no detected effect on pathogenicity, but one avr gene affected race specificity. Mol. Plant-Microbe Interact. 18: 1306-1317. DOI: 10.1094/MPMI-18-1306.
Qian W, Jia Y, Ren SX, He Y Q, Feng JX, Lu LF, Sun Q, Ying G, Tang DJ, Tang H, Wu W, Hao P, Wang L, Jiang BL, Zeng S, Gu WY, Lu G, Rong L, Tian Y, Yao Z, Fu G, Chen B, Fang R, Qiang B, Chen Z, Zhao GP, Tang JL and He C (2005). Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris. Genome Research 15: 757-767. DOI: 10.1101/gr.3378705.
Wang L, Tang X, He C (2007). The bifunctional effector AvrXccC of Xanthomonas campestris pv. campestris requires plasma membrane-anchoring for host recognition. Mol. Plant Pathol. 8: 491-501. DOI: 10.1111/j.1364-3703.2007.00409.x.
